Publications and clinical trials

We intend to decisively advance telemedicine and AI-based diagnostics of anterior segment eye diseases.  Therefore, academic work is at the heart of our business and we place great emphasis on collaboration with academic institutions.

Occyo is currently conducting clinical trials in Milan and Brescia in Italy. Furthermore, our first clinical trial was finished at Paracelsus Medical University of Salzburg.

In the first clinical trials, eyes with various ocular surface pathologies are imaged, including penetrating corneal grafts, corneal foreign bodies, superficial punctate keratitis, and microbial conjunctivitis.

These patients are typically seen in an ophthalmic outpatient clinic and were included in the studies to demonstrate the capabilities of our novel imaging solution. 

 

Occyo related scientific publications 

2023

  1. Augustin, M., Ostheimer, P., Hausmann U., Baumgarten, D., Romano V., Steger B. An imaging system for standardized and enhanced photographs of the ocular surface. Investigative Ophthalmology & Visual Science Jun 2023; 64(9), PB95. An imaging system for standardized and enhanced photographs of the ocular surface | IOVS | ARVO Journals

  2. Augustin, M., Ostheimer, P., Hausmann U., Baumgarten, D., Romano V., Steger B. Standardized Imaging of the Ocular Surface Using a Novel External Eye Photography System. Investigative Ophthalmology & Visual Science. Jun 2023; 64 (8), 3405-3405. Standardized Imaging of the Ocular Surface Using a Novel External Eye Photography System | IOVS | ARVO Journals

  3. Ostheimer, P., Lins A., Steger B., Romano V., Augustin A., Baumgarten, D., Ocular surface redness determination using a novel photography system with reference to clinical gradings. Investigative Ophthalmology & Visual Science 64 (8), 2379-2379. ARVO Journals

  4. M Schweitzer, K Flórez, B Steger, D Baumgarten, V Romano, M Augustin. Integrating a Novel Eye Imaging System into Clinical Practice: An Open-Source DICOM Simulation Platform. Studies in Health Technology and Informatics 301, 198-203. PubMed

Also Occyo was mentioned in:

  1. De Luca, A.; Ferraro, A.; De Gregorio, C.; Laborante, M.; Coassin, M.; Sgrulletta, R.; Di Zazzo, A. Promising High-Tech Devices in Dry Eye Disease Diagnosis. Life 2023, 13, 1425. Promising High-Tech Devices in Dry Eye Disease Diagnosis

2022

  1. Schweitzer, M., Steger, B., Hörbst, A., Augustin, M., Pfeifer, B., Hausmann, U., & Baumgarten, D. (2022, May). Data Exchange Standards in Teleophthalmology: Current and Future Developments. In dHealth (pp. 270-277).

  2. Ostheimer, P., Lins, A., Massow, B., Steger, B., Baumgarten, D. and Augustin, M., 2022. Extraction of Eye Redness for Standardized Ocular Surface Photography. In International Workshop on Ophthalmic Medical Image Analysis (pp. 193-202). Springer, Cham.

  3. Ostheimer, P., Lins, A., Massow, B., Steger, B., Augustin, M., Baumgarten, D., Automated identification of the sclera in high-resolution ocular surface images of healthy subjects, Joint Annual Conference of the Austrian (ÖGBMT), German (VDE DGBMT) and Swiss (SSBE) Societies for Biomedical Engineering, Vol. 67, No. S1, 2022, pp. 1-580 (2022), https://doi.org/10.1515/bmt-2022-2001

  4. Romano V, Steger B, Ahmad M, Coco G, Pagano L, Ahmad S, Zhao Y, Zheng Y, Kaye SB. Imaging of vascular abnormalities in ocular surface disease. Surv Ophthalmol. 2022 Jan-Feb;67(1):31-51. doi: 10.1016/j.survophthal.2021.05.001. Epub 2021 May 13. PMID: 33992663.

2021

  1. Palme C, Wanner A, Romano V, Franchi A, Haas G, Kaye SB, Steger B.Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders. Cornea. 2021 Feb 15. doi: 10.1097/ICO.0000000000002681. Epub ahead of print. PMID: 33591034.

2020

  1. Palme C, Wanner A, Romano V, Haas G, Kaye S, Steger B (2020): Observation of angiographic dye leakage in ocular surface squamous neoplasia. Am J Ophthalmol Case Rep, 20:100912

  2. Palme C, Ahmad S, Romano V, et al. (2020): En-face analysis of the human limbal lymphatic vasculature. Exp Eye Res 201:108278.

  3. Williams BM, Borroni D, Liu R, Zhao Y, Zhang J, Lim J, Ma B, Romano V, Qi H, Ferdousi M, Petropoulos IN, Ponirakis G, Kaye S, Malik RA, Alam U, Zheng Y. An artificial intelligence-based deep learning algorithm for the diagnosis of diabetic neuropathy using corneal confocal microscopy: a development and validation study. Diabetologia. 2020 Feb;63(2):419-430. doi:10.1007/s00125-019-05023-4. Epub 2019 Nov 12. PMID: 31720728; PMCID: PMC6946763.

2019

  1. Romano  V,  Steger  B,  Brunner  M  (2019):  Detecting  change  in  conjunctival  hyperemia  using  a  pixel densitometry index. Ocul Immunol Inflamm 27(2):276-281.tbd

  2. Hausmann, U. (2019). Ophthalmoscope for examining eyes (WO 2021/119684 A1). 

2018

  1. Brunner M, Steger B, Romano V, et al. (2018): Identification of Feeder Vessels in Ocular Surface Neoplasia Using Indocyanine Green Angiography. Curr Eye Res 43:163–169.

  2. Palme C, Romano V, Brunner M, et al. (2018): Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography. Transl Vis Sci Technol 7:15.

  3. Brunner M, Romano V, Steger B, et al. (2018): Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography. Invest Ophthalmol Vis Sci 59:1263–1269.

  4. dell'Omo R, Cifariello F, De Turris S, Romano V, Di Renzo F, Di Taranto D, Coclite G, Agnifili L, Mastropasqua L, Costagliola C. Confocal microscopy of corneal nerve plexus as an early marker of eye involvement in patients with type 2 diabetes. Diabetes Res Clin Pract. 2018 Aug;142:393-400. doi:10.1016/j.diabres.2018.06.010. Epub 2018 Jun 21. PMID: 29935212.

  5. Brunner M, Romano V, Steger B, Vinciguerra R, Lawman S, Williams B, Hicks N, Czanner G, Zheng Y, Willoughby CE, Kaye SB. Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography. Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1263-1269. doi:10.1167/iovs.17-22035. PMID: 29625447.

  6. Liu S, Romano V, Steger B, Kaye SB, Hamill KJ, Willoughby CE. Gene-based antiangiogenic applications for corneal neovascularization. Surv Ophthalmol. 2018 Mar-Apr;63(2):193-213. doi:10.1016/j.survophthal.2017.10.006. Epub 2017 Nov 15. PMID: 29080632.

  7. Brunner M, Steger B, Romano V, Hodson M, Zheng Y, Heimann H, Kaye SB. Identification of Feeder Vessels in Ocular Surface Neoplasia Using Indocyanine Green Angiography. Curr Eye Res. 2018 Feb;43(2):163-169. doi:10.1080/02713683.2017.1387273. Epub 2017 Nov 7. PMID: 29111820.

  8. Steger B, Romano V, Kaye SB. Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. Ocul Immunol Inflamm. 2018;26(5):685-688. doi:10.1080/09273948.2016.1247873. Epub 2016 Nov 30. PMID: 27901637.

2017

  1. Gasser T, Romano V, Seifarth C, Bechrakis NE, Kaye SB, Steger B.Morphometric characterisation of pterygium associated with corneal stromal scarring using high-resolution anterior segment optical coherence tomography. Br J Ophthalmol. 2017 May;101(5):660-664. doi: 10.1136/bjophthalmol-2016-308685.Epub 2016 Aug 3. PMID: 27488179.

2016

  1. Steger B, Romano V, Kaye SB (2016): Corneal indocyanine green angiography to guide medical and surgical management of corneal neovascularization. Cornea 35:41-45.

  2. Romano V, Steger B, Brunner M, Ahmad S, Willoughby CE, Kaye SB. Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization. Cornea. 2016 Jul;35(7):1029-32. doi: 10.1097/ICO.0000000000000865. PMID: 27149536.

2015

  1. Romano V, Steger B, Zheng Y, Ahmad S, Willoughby CE, Kaye SB. Angiographic and In Vivo Confocal Microscopic Characterization of Human Corneal Blood and Presumed Lymphatic Neovascolarization: A Pilot Study. Cornea. 2015 Nov;34(11)